Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease
| Autor: | Tomone Nagae, Keizo Takeshita, Shinsuke Ifuku, Daisuke Iohara, Makoto Anraku, Kaneto Uekama, Masaki Otagiri, Fumitoshi Hirayama, Shoko Okazaki, Takako Ishiguro, Ryo Tabuchi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Polymers and Plastics Prednisolone Nanofibers Chitin Ether 02 engineering and technology Pharmacology medicine.disease_cause 030226 pharmacology & pharmacy Inflammatory bowel disease Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration Materials Chemistry medicine Animals Rats Wistar Colitis Mice Inbred ICR Chemistry Dextran Sulfate beta-Cyclodextrins Organic Chemistry Inflammatory Bowel Diseases 021001 nanoscience & nanotechnology medicine.disease Controlled release Rats Solubility Biochemistry Delayed-Action Preparations 0210 nano-technology Gels Oxidative stress medicine.drug |
| Zdroj: | Carbohydrate Polymers. 174:1087-1094 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2017.07.028 |
| Popis: | Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE-β-CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. PD was released slowly from the gel at both pH 1.2 and 6.8. The in vitro slow release of PD from the NFs-CDs gel was reflected in the in vivo absorption of the drug after oral administration to rats. These results suggest that a simple gel composed of a mixture of SDACNFs and SBE-β-CD has the potential for use in the controlled release of PD. We also evaluated the therapeutic effects of the NFs-CDs gel containing PD on dextran sulfate sodium (DSS)-induced colitis model mice. The administration of the NFs-CDs gel at intervals of 3days from the beginning of the DSS treatment resulted in a significant improvement, not only in colitis symptoms but also histopathological changes in colon tissue. In addition, the therapeutic effects of the NFs-CDs gel on colitis can be attributed to decreased levels of neutrophil infiltration and the development of oxidative stress. These efficacy profiles of the NFs-CDs gel containing PD suggest that it has the potential for use in the treatment of, not only colitis, but also a variety of other disorders associated with inflammation and oxidative injuries. |
| Databáze: | OpenAIRE |
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