Application of contrast-enhanced dual-energy spectral CT for differentiating borderline from malignant epithelial ovarian tumours
| Autor: | Y. Li, Ailian Liu, B. Li, Jian-Ying Li, Mei-Yu Sun, Xiaohong Han |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
media_common.quotation_subject Contrast Media Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Humans Contrast (vision) Medicine Radiology Nuclear Medicine and imaging Neoplasms Glandular and Epithelial Ovarian tumours Aged Retrospective Studies media_common Ovarian Neoplasms Solid tumour Receiver operating characteristic Dual energy business.industry Attenuation Ovary Reproducibility of Results General Medicine Middle Aged Radiographic Image Enhancement 030220 oncology & carcinogenesis Female Tomography X-Ray Computed business Material decomposition Nuclear medicine Arterial phase |
| Zdroj: | Clinical Radiology. 76:585-592 |
| ISSN: | 0009-9260 |
| DOI: | 10.1016/j.crad.2021.04.004 |
| Popis: | To investigate the value of contrast-enhanced dual-energy spectral computed tomography (CT) in differentiating borderline epithelial ovarian tumours (BEOTs) from malignant epithelial ovarian tumours (MEOTs).Sixty patients who underwent pelvic contrast-enhanced spectral CT were divided into two groups for analysis based on the tumour types confirmed at histopathological examination (26 BEOTs and 34 MEOTs). The regions of interest (ROIs) were selected on solid tumour components to measure attenuation values on monochromatic image sets (40-140 keV) in all imaging phases and tumour iodine concentrations (IC) on material decomposition images. Differences in the attenuation value between the unenhanced and contrast-enhanced phases (enhancement degree) and between energy strengths (slope k, k = [attenuation at 40 keV- attenuation at 140 keV]/100) were calculated. All measurements between the two groups were compared with independent t-test. Receiver operating characteristic (ROC) curves were generated to calculate the sensitivity, specificity and area under the ROC curve (AUC). Logistic regression analysis was used to evaluate the diagnostic efficacy of using combined parameters in two-phase contrast-enhanced images.In the arterial phase (AP) and venous phase (VP), the BEOTs had significantly lower enhancement than MEOTs from 40 to 100 keV (p0.05). The k values and IC values both showed significant differences in the AP and VP (p0.05). Combining parameters in two contrast-enhanced phases provided 80.8% sensitivity and 82.4% specificity in differentiating MEOTs from BEOTs with an AUC of 0.844.Dual-energy spectral CT provides a multiparametric approach in differentiating BEOTs from MEOTs with the best diagnostic efficacy using combined parameters in the AP and VP images. |
| Databáze: | OpenAIRE |
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