The interleukin 2 receptor in the hypereosinophilic syndrome
| Autor: | Valérie Gruart, Monique Capron, Joël Plumas, André Capron, Lionel Prin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
Cancer Research Pathology medicine.medical_specialty Hypereosinophilia Eosinophilia medicine Humans Receptor reproductive and urinary physiology Heterogeneous group Hypereosinophilic syndrome business.industry Receptors Interleukin-2 Hematology Syndrome medicine.disease Phenotype Eosinophils Oncology Immunology Interleukin-2 biological phenomena cell phenomena and immunity medicine.symptom business Infiltration (medical) Biomarkers medicine.drug |
| Zdroj: | Leukemialymphoma. 8(6) |
| ISSN: | 1042-8194 |
| Popis: | The hypereosinophilic syndrome (HES) has been previously described as a clinicobiological entity characterized by a blood eosinophil count of over 1.5 x 10(9)/L of unknown cause associated with several clinical complications. In reality, HES is a heterogeneous group of diseases with variable and unpredictable progress in visceral lesions, thought to be related to the deleterious effects of tissue eosinophil infiltration. Various criteria for discrimination between benign and severe forms of HES have been described. These previous retrospective clinical investigations, using biological and clinical markers, have defined different stages of HES. It appears more relevant, however, to consider elements of disease activity by studying mechanisms of induction of persistent hypereosinophilia. The T-cell dependence of blood eosinophilia has led us to evaluate various markers of T-cell activation in particular. In the present review, we report previous results and perspectives suggested by the study of the interleukin 2 receptor in HES. |
| Databáze: | OpenAIRE |
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