Hippocampal CA3 activation alleviates fMRI-BOLD responses in the rat prefrontal cortex induced by electrical VTA stimulation
Autor: | Thomas Scherf, Frank Angenstein |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Physiology lcsh:Medicine Hippocampus Stimulation Striatum Hippocampal formation Infographics Brain mapping Diagnostic Radiology methods [Brain Mapping] 0302 clinical medicine Animal Cells Functional Magnetic Resonance Imaging Medicine and Health Sciences lcsh:Science Prefrontal cortex Neurons Brain Mapping Multidisciplinary medicine.diagnostic_test Radiology and Imaging musculoskeletal neural and ocular physiology Brain Hematology physiology [Neurons] CA3 Region Hippocampal Magnetic Resonance Imaging Electrodes Implanted Electrophysiology Ventral tegmental area physiology [CA3 Region Hippocampal] medicine.anatomical_structure Anesthesia Anatomy Cellular Types Artifacts Graphs psychological phenomena and processes Research Article Computer and Information Sciences Neural Networks Imaging Techniques physiology [Prefrontal Cortex] Prefrontal Cortex Neurophysiology Surgical and Invasive Medical Procedures Neuroimaging Biology Research and Analysis Methods behavioral disciplines and activities Motion 03 medical and health sciences Diagnostic Medicine medicine Animals ddc:610 Rats Wistar physiology [Ventral Tegmental Area] Functional magnetic resonance imaging Neural networks Hemodynamics Functional electrical stimulation Functional Electrical Stimulation Data Visualization Ventral Tegmental Area lcsh:R Biology and Life Sciences Cell Biology Electric Stimulation Rats 030104 developmental biology nervous system Cellular Neuroscience lcsh:Q Neuroscience 030217 neurology & neurosurgery |
Zdroj: | PLoS ONE, Vol 12, Iss 2, p e0172926 (2017) PLoS ONE PLOS ONE, 12(2): e0172926 PLOS ONE 12(2), e0172926 (2017). doi:10.1371/journal.pone.0172926 |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0172926 |
Popis: | Functional magnetic resonance imaging (fMRI) was used to identify brain- wide networks that are activated by electrical stimulation of either the ventral tegmental area (VTA) or hippocampal CA3 region. Stimulation of either one of these regions caused significant BOLD responses in common structures, such as the septum and left and right hippocampus, but also in unique structures, such as the medial prefrontal cortex region/anterior cingulum region (mPFC/ACC) and striatum, which were only activated during VTA stimulation. Concurrent stimulations of the two structures resulted in no additive BOLD responses but significantly reduced BOLD responses in the mPFC/ACC when compared with sole VTA stimulation. This reduction is caused by costimulation of the hippocampal CA3 region, which was itself not sufficient to modify BOLD signal intensities in the mPFC/ACC. Under this experimental condition, functional connectivity between VTA and mPFC/ACC in terms of neurophysiological interactions was causative, driven by direct electrical stimulation of VTA projecting neurons, the resulting functional connectivity in terms of correlated BOLD time series becoming masked as soon as hippocampal projections concurrently coactivated mPFC neurons. This result warns against misinterpretation of the absence of functional connectivity in fMRI data sets, because strong existing neurophysiological interactions can be obscured by unrelated network activities. |
Databáze: | OpenAIRE |
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