High expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer

Autor: Xiuwu Tang, Min Li, Rong Rong, Xue Cheng, Youguo Chen, Yan Gao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Oncology
Cancer Research
Candidate gene
medicine.medical_specialty
Survival
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Fibroblast activation protein
alpha
Surgical oncology
High-grade serous ovarian cancer (HGSOC)
Internal medicine
Gene expression
Databases
Genetic
Endopeptidases
Genetics
Serous ovarian cancer
medicine
Humans
Gene
Neoplasm Staging
Ovarian Neoplasms
Proportional hazards model
business.industry
Fibroblast activation protein (FAP)
Serine Endopeptidases
Membrane Proteins
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Survival Analysis
Cystadenocarcinoma
Serous
Fibronectins
Up-Regulation
Gene Expression Regulation
Neoplastic
030104 developmental biology
Gelatinases
030220 oncology & carcinogenesis
Female
The Cancer genome atlas program (TCGA)
Ovarian cancer
business
Research Article
Signal Transduction
Zdroj: BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
ISSN: 1471-2407
Popis: Background High-grade serous ovarian cancer (HGSOC) is a fatal form of ovarian cancer. Previous studies indicated some potential biomarkers for clinical evaluation of HGSOC prognosis. However, there is a lack of systematic analysis of different expression genes (DEGs) to screen and detect significant biomarkers of HGSOC. Methods TCGA database was conducted to analyze relevant genes expression in HGSOC. Outcomes of candidate genes expression, including overall survival (OS) and progression-free survival (PFS), were calculated by Cox regression analysis for hazard rates (HR). Histopathological investigation of the identified genes was carried out in 151 Chinese HGSOC patients to validate gene expression in different stages of HGSOC. Results Of all 57,331 genes that were analyzed, FAP was identified as the only novel gene that significantly contributed to both OS and PFS of HGSOC. In addition, FAP had a consistent expression profile between carcinoma-paracarcinoma and early-advanced stages of HGSOC. Immunological tests in paraffin section also confirmed that up-regulation of FAP was present in advanced stage HGSOC patients. Prediction of FAP network association suggested that FN1 could be a potential downstream gene which further influenced HGSOC survival. Conclusions High-level expression of FAP was associated with poor prognosis of HGSOC via FN1 pathway.
Databáze: OpenAIRE
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