Determinants of low bone mineral density in children with epilepsy
| Autor: | Mazidah Noordin, Choong Yi Fong, Lai Choo Ong, Bee Koon Poh, Ching Ching Ng, Ann Nie Kong |
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| Rok vydání: | 2018 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Pediatrics Adolescent Genotype Parathyroid hormone 030209 endocrinology & metabolism Logistic regression Polymorphism Single Nucleotide 03 medical and health sciences Epilepsy 0302 clinical medicine Lumbar Bone Density Risk Factors Prevalence medicine Vitamin D and neurology Humans Vitamin D Child Bone mineral Lumbar Vertebrae business.industry Malaysia General Medicine Anthropometry medicine.disease Cross-Sectional Studies Parathyroid Hormone Child Preschool Pediatrics Perinatology and Child Health Physical therapy Anticonvulsants Calcium Female Neurology (clinical) Bone Diseases Underweight medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Paediatric Neurology. 22:155-163 |
| ISSN: | 1090-3798 |
| DOI: | 10.1016/j.ejpn.2017.10.007 |
| Popis: | Children with epilepsy on long-term antiepileptic drugs (AEDs) are at risk of low bone mineral density (BMD). The aims of our study were to evaluate the prevalence and determinants of low BMD among Malaysian children with epilepsy.Cross-sectional study of ambulant children with epilepsy on long-term AEDs for1 year seen in a tertiary hospital in Malaysia from 2014 to 2015. Detailed assessment of anthropometric measurements; environmental lifestyle risk factors; serum vitamin D, calcium and parathyroid hormone levels; genotyping of single nucleotide polymorphisms of genes in vitamin D and calcium metabolism; and lumbar spine BMD were obtained. Low BMD was defined as BMD Z-score ≤ -2.0 SD.Eighty-seven children with mean age of 11.9 years (56 males) participated in the study. The prevalence of low lumbar BMD was 21.8% (19 patients). Multivariate logistic regression analysis identified polytherapy2 AEDs (OR: 7.86; 95% CI 1.03-59.96), small frame size with wrist breadth of15th centile (OR 14.73; 95% CI 2.21-98.40), and body mass index Z-score -2.0 (OR 8.73, 95% CI 1.17-65.19) as significant risk factors for low BMD.One-fifth of Malaysian children with epilepsy on long-term AEDs had low BMD. Targeted BMD should be performed for those who are on2 AEDs, underweight or with small frame size as they are at higher risk of having low BMD. |
| Databáze: | OpenAIRE |
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