Targeting non-apoptotic cell death in cancer treatment by nanomaterials: Recent advances and future outlook
Autor: | Mohammad Raoufi, Mostafa Akbariani, Mohammad Reza Sepand, Mareike Müller, Mohammad Hossein Ghahremani, Sheyda Ranjbar, Ivan M. Kempson, Willis Collins Akeyo Muganda |
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Přispěvatelé: | Sepand, Mohammad Reza, Ranjbar, Sheyda, Kempson, Ivan M, Akbariani, Mostafa, Muganda, Willis Collins Akeyo, Muller, Mareike, Ghahremani, Mohammad Hossein, Raoufi, Mohammad |
Rok vydání: | 2020 |
Předmět: |
autophagy
Programmed cell death Necroptosis medicine.medical_treatment Biomedical Engineering necroptosis Pharmaceutical Science Medicine (miscellaneous) Apoptosis Bioengineering 02 engineering and technology 03 medical and health sciences Neoplasms Autophagy medicine Ferroptosis Humans cancer General Materials Science 030304 developmental biology 0303 health sciences Cell Death business.industry nanoparticle Cancer Immunotherapy Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease ferroptosis Nanostructures cell death Cancer cell Drug delivery Cancer research Molecular Medicine 0210 nano-technology business |
Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 29:102243 |
ISSN: | 1549-9634 |
Popis: | Many tumors develop resistance to most of the apoptosis-based cancer therapies. In this sense targeting non-apoptotic forms of cell death including necroptosis, autophagy and ferroptosis may have therapeutic benefits in apoptosis-defective cancer cells. Nanomaterials have shown great advantages in cancer treatment owing to their unique characteristics. Besides, the capability of nanomaterials to induce different forms of cell death has gained widespread attention in cancer treatment. Reports in this field reflect the therapeutic potential of necroptotic cell death induced by nanomaterials in cancer. Also, autophagic cell death induced by nanomaterials alone and as a part of chemo-, radio- and photothermal therapy holds great promise as anticancer therapeutic option. Besides, ferroptosis induction by iron-based nanomaterials in drug delivery, immunotherapy, hyperthermia and imaging systems shows promising results in malignancies. Hence, this review is devoted to the latest efforts and the challenges in this field of research and its clinical merits. Refereed/Peer-reviewed |
Databáze: | OpenAIRE |
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