International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance
| Autor: | Rudolf Daniel, Michaylov Nikolay, van der Linden Mark, Hoy Ludwig, Klugman Keith P, Welte Tobias, Pletz Mathias W, CAPNETZ Study Group |
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| Rok vydání: | 2011 |
| Předmět: |
Serotype
Scientific paradigm medicine.drug_class Antibiotics Population Biology medicine.disease_cause Microbiology 03 medical and health sciences Antibiotic resistance Mechanisms of Resistance Drug Resistance Multiple Bacterial Streptococcus pneumoniae medicine Humans Pharmacology (medical) Serotyping education 030304 developmental biology Pharmacology 0303 health sciences education.field_of_study 030306 microbiology Pneumonia Pneumococcal medicine.disease Anti-Bacterial Agents 3. Good health Community-Acquired Infections Pneumonia Infectious Diseases Multilocus sequence typing Multilocus Sequence Typing |
| Zdroj: | Antimicrobial agents and chemotherapy |
| DOI: | 10.1128/AAC.00250-11 |
| Popis: | A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia (CAP) were analyzed. Thirty percent showed a close relationship to international clones and had fitness equal to or exceeding that of other strains ( P = 0.015); these factors may result in the endurance of these strains despite a reduction of antibiotic usage. |
| Databáze: | OpenAIRE |
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