Characterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species
Autor: | Antonio Fernandez Guerra, Lone Gram, Claire Adams, Frank Oliver Glöckner, Jean-Baptiste Chabot, Alan D. W. Dobson, Kristian Fog Nielsen, Fiona A. Stewart, F. Reen, Fergal O'Gara, Marlies J. Mooij, Catriona Harrington |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
medicine.drug_class
Antibiotics Homoserine Pharmaceutical Science Context (language use) Tropodithietic acid Biology TDA Article Tropolone clinical Microbiology 03 medical and health sciences chemistry.chemical_compound Drug Discovery medicine Animals 14. Life underwater SDG 14 - Life Below Water Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Pseudovibrio 030304 developmental biology 0303 health sciences 030306 microbiology marine biology.organism_classification Antimicrobial Anti-Bacterial Agents Porifera Sponge Quorum sensing Biochemistry chemistry lcsh:Biology (General) abtimicrobial antimicrobial |
Zdroj: | Harrington, C, Reen, F J, Mooij, M J, Stewart, F A, Chabot, J-B, Guerra, A F, Glöckner, F O, Nielsen, K F, Gram, L, Dobson, A D W, Adams, C & O'Gara, F 2014, ' Characterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species. ', Marine Drugs, vol. 12, pp. 5960-5978 . https://doi.org/10.3390/md12125960 Marine Drugs, Vol 12, Iss 12, Pp 5960-5978 (2014) Marine Drugs Volume 12 Issue 12 Pages 5960-5978 |
Popis: | The search for new antimicrobial compounds has gained added momentum in recent years, paralleled by the exponential rise in resistance to most known classes of current antibiotics. While modifications of existing drugs have brought some limited clinical success, there remains a critical need for new classes of antimicrobial compound to which key clinical pathogens will be naive. This has provided the context and impetus to marine biodiscovery programmes that seek to isolate and characterize new activities from the aquatic ecosystem. One new antibiotic to emerge from these initiatives is the antibacterial compound tropodithietic acid (TDA). The aim of this study was to provide insight into the bioactivity of and the factors governing the production of TDA in marine Pseudovibrio isolates from a collection of marine sponges. The TDA produced by these Pseudovibrio isolates exhibited potent antimicrobial activity against a broad spectrum of clinical pathogens, while TDA tolerance was frequent in non-TDA producing marine isolates. Comparative genomics analysis suggested a high degree of conservation among the tda biosynthetic clusters while expression studies revealed coordinated regulation of TDA synthesis upon transition from log to stationary phase growth, which was not induced by TDA itself or by the presence of the C10-acyl homoserine lactone quorum sensing signal molecule.   |
Databáze: | OpenAIRE |
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