A second-generation linkage map of the human genome
| Autor: | Mark Lathrop, Jean Morissette, Alain Vignal, Jean Weissenbach, Gabor Gyapay, Guy Vaysseix, Philippe Millasseau, Colette Dib |
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| Rok vydání: | 1992 |
| Předmět: |
Genetic Markers
Linkage (software) Genetics Heterozygote Multidisciplinary Autosome Genotype Genetic Linkage Genome Human Chromosome Mapping Chromosome DNA Biology Polymerase Chain Reaction Gene mapping Genetic linkage Chromosomes Human Humans Human genome Repeated sequence Gene Library Repetitive Sequences Nucleic Acid Genomic organization |
| Zdroj: | Nature. 359:794-801 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/359794a0 |
| Popis: | A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome. |
| Databáze: | OpenAIRE |
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