Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance
| Autor: | Alessandra Carattoli, Shiri Navon-Venezia, Kira Kondratyeva |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
DNA Bacterial medicine.drug_class Klebsiella pneumoniae 030106 microbiology Antibiotics Drug resistance Biology Microbiology 03 medical and health sciences Plasmid Antibiotic resistance Bacterial Proteins Drug Resistance Multiple Bacterial medicine Humans Pathogen Aminoglycoside antibiotic agent antibiotic agent quinoline derived antiinfective agent bacterial DNA bacterial protein antibiotic resistance antibiotic resistance gene bacterial chromosome bacterial gene bacterial strain clone epidemic gene mutation genomics multidrug resistance nonhuman plasmid Review bacterial genome cross infection drug effects genetics human Klebsiella infection microbiology Bacterial Proteins Cross Infection Genome Bacterial Klebsiella Infections Plasmids Outbreak biology.organism_classification Virology Resistome Infectious Diseases |
| Zdroj: | FEMS microbiology reviews. 41(3) |
| ISSN: | 1574-6976 |
| Popis: | Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs). Under antibiotic selective pressure, K. pneumoniae continuously accumulates ARGs, by de novo mutations, and via acquisition of plasmids and transferable genetic elements, leading to extremely drug resistant (XDR) strains harboring a 'super resistome'. In the last two decades, numerous high-risk (HiR) MDR and XDR K. pneumoniae sequence types have emerged showing superior ability to cause multicontinent outbreaks, and continuous global dissemination. The data highlight the complex evolution of MDR and XDR K. pneumoniae, involving transfer and spread of ARGs, and epidemic plasmids in highly disseminating successful clones. With the worldwide catastrophe of antibiotic resistance and the urgent need to identify the main pathogens that pose a threat on the future of infectious diseases, further studies are warranted to determine the epidemic traits and plasmid acquisition in K. pneumoniae. There is a need for future genomic and translational studies to decipher specific targets in HiR clones to design targeted prevention and treatment. |
| Databáze: | OpenAIRE |
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