Asthma and IgE antibodies induced by chromium and nickel salts
| Autor: | Michael Habib, Ian D. Wells, Harold S. Novey |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
inorganic chemicals
Adult Chromium Male Allergy Immunology chemistry.chemical_element Immunoglobulin E Gold Sodium Thiomalate Radioallergosorbent Test Nickel Plating otorhinolaryngologic diseases medicine Immunology and Allergy Humans Asthma Skin Tests medicine.diagnostic_test biology Inhalation Radioallergosorbent test medicine.disease respiratory tract diseases Respiratory Function Tests Occupational Diseases chemistry biology.protein |
| Zdroj: | The Journal of allergy and clinical immunology. 72(4) |
| ISSN: | 0091-6749 |
| Popis: | Metal plating with chromium and nickel has secured an occupational relation with asthma for which an allergic basis has been postulated but not confirmed. A worker who developed de novo asthma after plating with nickel and chromium but not other metals was subjected to inhalational challenge and immunoserologic tests to evaluate this association. He developed acute asthma to chromium sulfate and a biphasic asthma-like response to nickel sulfate. Radioimmunoassays incorporating the challenge materials revealed specific IgE antibodies to the provocative agents but not to another metal, gold, which he could tolerate. The findings support the postulates that bronchial reactivity can be specifically induced by fumes of metallic salts, even in a previously nonallergic individual, and that an IgE type I immunopathogenic mechanism is involved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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