Multidisciplinary therapy consisting of minimally invasive resection, irradiation, and intra-arterial infusion of 5-fluorouracil for maxillary sinus carcinomas
| Autor: | Hiroshi Nishino, Takeharu Kanazawa, Kazumi Kawada, Masanori Nakazawa, Minako Takanosawa, Keiichi Ichimura, Satoru Takahashi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Antimetabolites Antineoplastic medicine.medical_specialty Visual acuity Maxillary sinus Maxillary Sinus Neoplasms Fistula Kaplan-Meier Estimate Trismus Resection Quality of life medicine Humans Infusions Intra-Arterial Neoplasm Invasiveness Retrospective Studies business.industry Carcinoma Intra arterial infusion Maxillary Sinus Middle Aged medicine.disease Surgery Survival Rate medicine.anatomical_structure Otorhinolaryngology Fluorouracil Lymphatic Metastasis Female Radiotherapy Adjuvant Neoplasm Recurrence Local medicine.symptom business Orbit Follow-Up Studies medicine.drug |
| Zdroj: | Head & Neck. 35:772-778 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.23030 |
| Popis: | Background Current goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure. Methods Japanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra-arterial infusion of 5-fluorouracil. Results The 5- and 10-year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5- and 10-year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients). Conclusion A multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 |
| Databáze: | OpenAIRE |
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