Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 - a review

Autor: Christine M. Akamine, Hana M. El Sahly
Rok vydání: 2021
Předmět:
PAMPs
Pathogen-associated molecular patterns
COVID-19 Vaccines
MERS-CoV
Middle east respiratory syndrome coronavirus
CVnCOV
CureVac
VOC
Variants of concern
Review Article
BMI
Body mass index
COVID-NET
COVID-19-Associated Hospitalization Surveillance Network
DCs
Dendritic cells
EUA
Emergency use authorization
mRNA
Messenger ribonucleic acid
dsRNA
Double-stranded RNA
GMC
Geometric mean concentration
Physiology (medical)
SAM
Self-amplifying mRNA
COVID-19
Coronavirus disease of 2019
Humans
LNP
Liposomal nanoparticle
CDC
Centers for Disease Control
RNA
Messenger
Ad5
Adenovirus type 5
ACE-2
Angiotensin converting enzyme receptor
Pandemics
BNT162 Vaccine
B.1.1.7
Alpha variant
MHC
Major histocompatibility complex
Vaccines
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
B.1.351
Beta variant
SARS-CoV-2
Biochemistry (medical)
Public Health
Environmental and Occupational Health
COVID-19
General Medicine
FDA
Food and Drug Administration
GMT
Geometric mean titer
BAU
binding antibody units
APCs
Antigen presenting cells
UTR
Untranslated regions
VAERS
Vaccine adverse event reporting system
RBD
Receptor-binding domain
Zdroj: Translational Research
ISSN: 1878-1810
Popis: The mRNA therapeutics have been studied since the 1970s and the currently available mRNA vaccines against COVID-19 are the culmination of decades of scientific research. The mRNA vaccines BNT162b2 and mRNA-1273 have played a key role in our global response to the COVID-19 pandemic as they have demonstrated significant advantages over conventional vaccines and have proven to be highly effective against COVID-19 associated hospitalization and severe illness in large clinical trials and studies using real-world data.
Databáze: OpenAIRE
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