In vivo ameliorative effects of methanol leaf extract of Lawsonia inermis Linn on experimental Trypanosoma congolense infection in Wistar rats
| Autor: | Patricia Ishaku Kobo, Salisu Hashim Shittu, B. Habibu, Mohammed M. Suleiman, Peter Ofemile Yusuf, Mohammed Umar Kawu, Abdullah Mohammad Tauheed |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Phytochemistry Antioxidant 040301 veterinary sciences medicine.medical_treatment Pharmacology Biology 0403 veterinary science Terpene 03 medical and health sciences chemistry.chemical_compound In vivo Malondialdehyde medicine chemistry.chemical_classification lcsh:Veterinary medicine General Veterinary Glycoside Antitrypanosomal 04 agricultural and veterinary sciences 030104 developmental biology Lawsonia inermis chemistry Biochemistry Phytochemical Erythrocyte osmotic fragility lcsh:SF600-1100 |
| Zdroj: | International Journal of Veterinary Science and Medicine, Vol 4, Iss 2, Pp 33-40 (2016) |
| ISSN: | 2314-4599 |
| Popis: | The aim of this study was to investigate the ameliorative effect of Lawsonia inermis Linn used traditionally against trypanosomosis. Twenty-five adult Wistar rats of both sex were individually infected intraperitoneally (IP) with 106 Trypanosoma congolense per ml of blood. Following establishment of infection, the rats were randomly divided into five groups of 5 rats each. Rats in groups I, II, and III were treated with 125, 250 and 500 mg/kg of the extract, respectively, while rats in groups IV and V were treated with 3.5 mg/kg and 2 ml/kg of diminazene aceturate (DM) once and physiological buffered saline, respectively. All treatments except DM were given orally for 7 days IP. The antitrypanosomal effect of the plant was assessed by observing the level of parasitaemia daily, packed cell volume (PCV) weekly, erythrocyte osmotic fragility (EOF) and malondialdehyde (MDA) concentration on day 21. Phytochemical screening of the extract revealed the presence of alkaloids, carbohydrates, triterpenes, steroids, cardiac glycosides, saponins, tannins and flavonoids. The extract significantly (P 0.05) in extract treated groups but significantly higher (P |
| Databáze: | OpenAIRE |
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