Serotonin and 5-HT2B receptors in microglia control of behavior
| Autor: | Luc Maroteaux, Catherine Béchade, Ivana D’Andrea |
|---|---|
| Přispěvatelé: | Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Psychosis
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Central nervous system microglia Inflammation Disease Major depressive disorder 03 medical and health sciences 0302 clinical medicine neurodegenerative disease medicine Amyotrophic lateral sclerosis 030304 developmental biology 0303 health sciences Microglia business.industry [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology medicine.disease 3. Good health serotonin schizophrenia [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics medicine.anatomical_structure Schizophrenia inflammation [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Serotonin medicine.symptom business 5-HT 2B receptor Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | HANDBOOK OF THE BEHAVIORAL NEUROBIOLOGY OF SEROTONIN HANDBOOK OF THE BEHAVIORAL NEUROBIOLOGY OF SEROTONIN, pp.589-599, 2020, ⟨10.1016/B978-0-444-64125-0.00034-7⟩ |
| DOI: | 10.1016/B978-0-444-64125-0.00034-7⟩ |
| Popis: | International audience; Serotonin has been widely involved in neuropsychiatric diseases, including major depressive disorders, or schizophrenia, and in neurodegenerative diseases, including Alzheimer's disease or amyotrophic lateral sclerosis. Independent evidence also suggests the contribution of inflammatory mediators in these pathologies. Indeed, peripheral infections as well as chronic diseases of the central nervous system cause activation of microglia, the resident macrophages of the brain. Emerging evidence indicate that serotonin might regulate brain inflammation, either developmentally, acutely, or during neurodegenerative diseases, and in turn influence the course of these diseases. In this review, we summarize evidence for serotonin involvement via 5-HT 2B receptors in inflammatory responses in central nervous system. We show how microglial activation may participate in behavioral changes associated to pathologies including depression, psychosis and neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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