Aromatization as an Impetus to Harness Ketones for Metallaphotoredox-Catalyzed Benzoylation/Benzylation of (Hetero)arenes

Autor:	Shao-Chi Lee, Li-Yun Li, Zong-Nan Tsai, Yi-Hsin Lee, Yong-Ting Tsao, Pin-Gong Huang, Cheng-Ku Cheng, Heng-Bo Lin, Ting-Wei Chen, Chung-Hsin Yang, Cheng-Chau Chiu, Hsuan-Hung Liao
Rok vydání:	2021
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:85-89
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03672
Popis:	Herein we report ketones as feedstock materials in radical cross-coupling reactions under Ni/photoredox dual catalysis. In this approach, simple condensation first converts ketones into prearomatic intermediates that then act as activated radical sources for cross-coupling with aryl halides. Our strategy enables the direct benzylation/benzoylation of (hetero)arenes under mild reaction conditions with high functional group tolerance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f82a92a826c73181f2ff5ff448c0f2 https://doi.org/10.1021/acs.orglett.1c03672 Zobrazit plný text záznamu