The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry

Autor:	Timothy W. Morris, Michael C. Davis, Paul J. Renick, Shari S. Soper, A. Greg Switzer, David Robert Jones, Shyam Sunder, Christian N. Parker, Qimin Wu, Mark Edward Stella, Paul M. Hershberger, Lawrence J. Wilson, Helana D. McKeever, Gary Paul Shrum, Thomas M Burt, Kenneth L. Morand, Roy L. M. Dobson
Rok vydání:	2001
Předmět:	Chemical Phenomena Gram-positive bacteria Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Chemical synthesis Mass Spectrometry Bacterial cell structure Cell wall Cell Wall Drug Discovery medicine Combinatorial Chemistry Techniques Urea Molecular Biology Chromatography High Pressure Liquid Antibacterial agent Bacteria biology Chemistry Physical Chemistry Organic Chemistry biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents Hydrazines Mechanism of action Molecular Medicine medicine.symptom Antibacterial activity
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:1149-1152
ISSN:	0960-894X
Popis:	An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f81ce84d0aafb593d2a8b073aeb1c6 https://doi.org/10.1016/s0960-894x(01)00160-3 Zobrazit plný text záznamu Full Text from ScienceDirect