Autor: |
Timothy W. Morris, Michael C. Davis, Paul J. Renick, Shari S. Soper, A. Greg Switzer, David Robert Jones, Shyam Sunder, Christian N. Parker, Qimin Wu, Mark Edward Stella, Paul M. Hershberger, Lawrence J. Wilson, Helana D. McKeever, Gary Paul Shrum, Thomas M Burt, Kenneth L. Morand, Roy L. M. Dobson |
Rok vydání: |
2001 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 11:1149-1152 |
ISSN: |
0960-894X |
Popis: |
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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