Immune response to tetanus booster in infants aged 15 months born prematurely with very low birth weight
| Autor: | Maria Isabel de Moraes-Pinto, Raquel Maria Simão-Gurge, Maria Cristina Abrão Aued Perin, Amélia Miyashiro Nunes dos Santos, Ana Lucia Goulart, Carolina Frank Schlindwein, Ana Flavia de Mello Almada Mimica |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP) |
| Rok vydání: | 2012 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Cellular immunity Pediatrics medicine.medical_specialty Birth weight Immunization Secondary Enzyme-Linked Immunosorbent Assay Premature infant CD8-Positive T-Lymphocytes Interferon-gamma Young Adult Tetanus toxoid Immunology and Microbiology(all) medicine Tetanus Toxoid Humans Infant Very Low Birth Weight Prospective Studies Full Term Aged Tetanus General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Infant Newborn Gestational age Infant medicine.disease Flow Cytometry veterinary(all) Antibodies Bacterial Low birth weight Humoral immunity Infectious Diseases biology.protein Molecular Medicine Immunization Female Antibody medicine.symptom business |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1873-2518 |
| Popis: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objectives: To compare humoral and cellular immune responses to tetanus booster vaccination in infants born prematurely with those born at full term and identify factors associated with the humoral response.Methods: A prospective study was carried out on children born prematurely and with a birth weight 6 months was associated with a 3.5-fold greater chance of optimal protective (>= 0.1 IU/mL) antibody level against tetanus at 15 months and an increase of 0.956 in the level of antibodies at 18 months.Conclusions: Humoral and cellular response following a tetanus booster was similar in both groups. Premature infants exhibited lower levels of anti-tetanus antibodies at 15 months of age, with the lowest levels in those born at a gestational age of less than 32 weeks. Breastfeeding was associated with greater levels of antibody against tetanus. (C) 2012 Elsevier B.V. All rights reserved. Universidade Federal de São Paulo, Neonatal Div Med, Dept Pediat, São Paulo, Brazil Universidade Federal de São Paulo, Div Pediat Infect Dis, Dept Pediat, São Paulo, Brazil Universidade Federal de São Paulo, Neonatal Div Med, Dept Pediat, São Paulo, Brazil Universidade Federal de São Paulo, Div Pediat Infect Dis, Dept Pediat, São Paulo, Brazil FAPESP: 06/51865-8 FAPESP: 09/14351-4 Web of Science |
| Databáze: | OpenAIRE |
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