Polymerizing Insulin with Photocleavable Linkers to Make Light-Sensitive Macropolymer Depot Materials
| Autor: | Simon H. Friedman, Piyush K. Jain, Bhagyesh R. Sarode |
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| Rok vydání: | 2016 |
| Předmět: |
Light
Polymers and Plastics Polymers medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Bioengineering Context (language use) Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Article Polymerization Biomaterials chemistry.chemical_compound Materials Chemistry medicine Humans Insulin Dimethyl Sulfoxide chemistry.chemical_classification Photolysis Aqueous solution Chemistry Polymer 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Kinetics Monomer Click chemistry Azide 0210 nano-technology Biotechnology |
| Zdroj: | Macromolecular Bioscience. 16:1138-1146 |
| ISSN: | 1616-5187 |
| Popis: | The use of light sensitive polymers for the release of therapeutics is an important approach allowing the timing and amount of the release to be controlled precisely. We have pioneered the use of light to control insulin release from a dermal photoactivated depot, or PAD. One of the main impediments to the use of light sensitive polymers in this context is the density of the materials: The large majority of the material is the carrier polymer, with the minority being the therapeutic. In this work, we demonstrate the feasibility of using insulin itself as a monomer in the polymerization process. We use insulin modified with either one or two light cleavable azide groups and polymerize them with a tridentate alkyne bridging monomer using a click reaction. The resulting material which we call a “macropolymer” is ~90% insulin, is insoluble in aqueous solvent and releases native, soluble insulin upon irradiation. |
| Databáze: | OpenAIRE |
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