Marathoners' Breathing Pattern Protects Against Lung Injury by Mechanical Ventilation: An Ex Vivo Study Using Rabbit Lungs
| Autor: | Yoshiaki Oshima, Akihiro Otsuki, Tomomi Harada, Shunsaku Takahashi, Kazumi Funaki, Naoto Okazaki, Yoshimi Inagaki |
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| Rok vydání: | 2020 |
| Předmět: |
Oncotic pressure
medicine.medical_specialty Respiratory rate medicine.medical_treatment Lung injury perfused lung 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Tidal volume Mechanical ventilation Lung lung-protective ventilation strategy business.industry ventilator-induced lung injury General Medicine respiratory system respiratory tract diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Breathing Cardiology 030211 gastroenterology & hepatology Original Article 2:2 breathing rhythm marathon Airway business |
| Zdroj: | Yonago Acta Med Oshima Yoshiaki, Okazaki Naoto, Funaki Kazumi, et al. Marathoners’ Breathing Pattern Protects Against Lung Injury by Mechanical Ventilation: An Ex Vivo Study Using Rabbit Lungs. 2020, 63(4). 272-281. doi:10.33160/yam.2020.11.005 |
| ISSN: | 0513-5710 |
| DOI: | 10.33160/yam.2020.11.005 |
| Popis: | BACKGROUND: Breathing during a marathon is often empirically conducted in a so-called “2:2 breathing rhythm,” which is based on a four-phase cycle, consisting of the 1st and 2nd inspiratory and the 1st and 2nd expiratory phases. We developed a prototype ventilator that can perform intermittent positive pressure ventilation, mimicking the breathing cycle of the 2:2 breathing rhythm. This mode of ventilation was named the marathoners’ breathing rhythm ventilation (MBV). We hypothesized that MBV may have a lung protective effect. METHODS: We examined the effects of the MBV on the pulmonary pre-edema model in isolated perfused rabbit lungs. The pulmonary pre-edema state was induced using bloodless perfusate with low colloid osmotic pressure. The 14 isolated rabbit lung preparations were randomly divided into the conventional mechanical ventilation (CMV) group and MBV group, (both had an inspiratory/expiratory ratio of 1/1). In the CMV group, seven rabbit lungs were ventilated using the Harvard Ventilator 683 with a tidal volume (TV) of 8 mL/kg, a respiratory rate (RR) of 30 cycles/min, and a positive end-expiratory pressure (PEEP) of 2 cmH(2)O for 60 min. In the MBV group, seven rabbit lungs were ventilated using the prototype ventilator with a TV of 6 mL/kg, an RR of 30 cycles/min, and a PEEP of 4 cmH(2)O (first step) and 2 cmH(2)O (second step) for 60 min. The time allocation of the MBV for one cycle was 0.3 s for each of the 1st and 2nd inspiratory and expiratory phases with 0.2 s of intermittent resting between each phase. RESULTS: Peak airway pressure and lung wet-to-dry ratio after 60 min of ventilation were lower in the MBV group than in the CMV group. CONCLUSION: MBV was considered to have a lung-protective effect compared to CMV. |
| Databáze: | OpenAIRE |
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