Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese Medicinal: effect on severe aplastic anemia
| Autor: | Feng Liu, Chun-mei Zheng, Chi Liu, Shu Xu, Xudong Tang, Haiyan Xiao, Shan-shan Zhang, Liu Li, Rou Ma |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Antilymphocyte serum medicine.medical_specialty Adolescent Globulin Anemia Gastroenterology Reinforcing kidney Young Adult Reticulocyte Internal medicine medicine Humans Young adult Child Survival rate Antithymocyte serum Medicine(all) Kidney biology business.industry General Medicine Middle Aged medicine.disease Anemia aplastic Survival Rate Treatment Outcome medicine.anatomical_structure Immunology biology.protein Drugs Chinese herbal Female Hemoglobinuria Hemoglobin business |
| Zdroj: | Journal of Traditional Chinese Medicine. 32:604-608 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(13)60078-3 |
| Popis: | Objective To explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on severe aplastic anemia (SAA). Methods Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009, and the clinical data before and after treatment were collected and analyzed. Results Of the 25 patients, 9 were nearly cured, 6 were improved, 5 were in remission, and 5 failed. The overall effective rate was 80.0%. The 3-year, 5-year, 10-year, 15-year survival rate were respectively 98.6%, 97.3%, 97.3%, 67.5%, and median survival time was 180 months. Compared to the conditions before administering the medication of ATG/ALG plus KNCM, after 2 weeks, reticulocyte was first improved ( P =0.001); one month later, followed by palette ( P =0.037); two months later, by neutrophil cell in peripheral blood ( P =0.001); three months later, then by the hemoglobin ( P =0.012). By conducting 1-year follow-up, 1 case of complication–paroxysmal nocturnal hemoglobinuria (PNH) was identified and the patient still alive today. Conclusion ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate. |
| Databáze: | OpenAIRE |
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