Potential Effect of Previous Human Coronavirus NL63 Infection on the Rate of Infection and the Clinical Course of Coronavirus Disease 2019
| Autor: | E Korkut, E Veledar, H Avdihodžić, M Hukić |
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| Rok vydání: | 2021 |
| Předmět: |
Human coronavirus NL63
Adult Male 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Adolescent Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Enzyme-Linked Immunosorbent Assay Cross Reactions Antibodies Viral Cohort Studies Young Adult Germany antibody Major Article Immunology and Allergy Medicine Humans Letter to the Editor Respiratory Tract Infections Aged Aged 80 and over biology Respiratory tract infections business.industry SARS-CoV-2 Potential effect Clinical course Coronavirus virus diseases COVID-19 Middle Aged neutralization biology.organism_classification Virology Antibodies Neutralizing Immunity Humoral Immunoglobulin A Coronavirus NL63 Human Infectious Diseases HEK293 Cells AcademicSubjects/MED00290 Immunoglobulin G Female business |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 |
| Popis: | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and hundreds of thousands of deaths. The infection causes coronavirus disease 2019 (COVID-19), a disease of the respiratory system of divergent severity. In the current study, humoral immune responses were characterized in a cohort of 143 patients with COVID-19 from the University Hospital Frankfurt am Main, Germany.SARS-CoV-2-specific-antibodies were detected by enzyme-linked immunosorbent assay (ELISA). SARS-CoV-2 and human coronavirus NL63 neutralization activity was analyzed with pseudotyped lentiviral vectors.The severity of COVID-19 increased with age, and male patients encountered more serious symptoms than female patients. Disease severity was correlated with the amount of SARS-CoV-2-specific immunoglobulin (Ig) G and IgA and the neutralization activity of the antibodies. The amount of SARS-CoV-2-specific IgG antibodies decreased with time after polymerase chain reaction conformation of the infection, and antibodies directed against the nucleoprotein waned faster than spike protein-directed antibodies. In contrast, for the common flu coronavirus NL63, COVID-19 disease severity seemed to be correlated with low NL63-neutralizing activities, suggesting the possibility of cross-reactive protection.The results describe the humoral immune responses against SARS-CoV-2 and might aid the identification of correlates of protection needed for vaccine development. |
| Databáze: | OpenAIRE |
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