Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
| Autor: | Sini Flückiger-Isler, Tobias Schulze, Stefanie Lohrmann, Mahmoud Bataineh, Werner Brack, Jiri Neca, Urte Lübcke-von Varel, Ivonne Löffler, Miroslav Machala |
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| Rok vydání: | 2011 |
| Předmět: |
endocrine system
Geologic Sediments 3-Nitrobenzanthrone Aquatic organisms chemistry.chemical_compound Human health Salmonella Germany Benz(a)Anthracenes Humans Polycyclic Aromatic Hydrocarbons lcsh:Environmental sciences General Environmental Science lcsh:GE1-350 Chemistry Mutagenicity Tests Industrial area fungi Sediment food and beverages Contamination Environmental chemistry Lc apci ms ms Mutagenicity Test Water Pollutants Chemical Environmental Monitoring Mutagens |
| Zdroj: | Environment International, Vol 44, Iss, Pp 31-39 (2012) |
| ISSN: | 1873-6750 |
| Popis: | Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several secondary and tertiary fractions. Dinitropyrenes and 3-nitrobenzanthrone could be confirmed to contribute great shares of the observed mutagenicity. In addition, a multitude of polar polycyclic aromatic compounds has been tentatively identified in mutagenic fractions including nitro-PAHs, azaarenes, ketones, quinones, hydroxy-compounds, lactones and carboxylic acids although their contribution to mutagenicity could not be quantified due to a lack of standards. Diagnostic Salmonella strains YG1024 and YG1041 were applied to confirm the contribution of nitro-aromatic compounds. We suggest the inclusion of dinitropyrenes and 3-nitrobenzanthrone into sediment monitoring in order to minimize the mutagenic risk to aquatic organisms and to human health. Keywords: Effect-directed analysis, Mutagen identification, Nitro-PAH, Ames fluctuation assay, LC–(APCI-)MS/MS |
| Databáze: | OpenAIRE |
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