Impaired Left Atrial Reservoir Function in Metabolic Syndrome Predicts Symptoms in HFpEF Patients
| Autor: | Michael Y. Henein, Nehat Rexhepaj, Gani Bajraktari, Gëzim Berisha, Pranvera Ibrahimi, I. Bytyci, Shpend Elezi |
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| Rok vydání: | 2015 |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty Ejection fraction Reservoir function business.industry lcsh:R heart failure lcsh:Medicine medicine.disease Metabolic syndrome Coronary artery disease Endocrinology Increased risk lcsh:RC666-701 Left atrial Internal medicine Heart failure medicine Cardiology Mass index left atrial function business |
| Zdroj: | International Cardiovascular Forum Journal, Vol 4, Pp 37-42 (2015) |
| ISSN: | 2409-3424 2410-2636 |
| DOI: | 10.17987/icfj.v4i0.171 |
| Popis: | Background and Aim. The Metabolic Syndrome (MetS) has been shown to be independently associated with increased risk for incident heart failure (HF) and coronary artery disease. The aim of this study was to investigate the additional effect of MetS on LA dysfunction in a group of patients with HF and preserved ejection fraction (HFpEF) and its relationship with symptoms.Methods. This study included 194 consecutive patients (age 62 ± 9 years) with stable HFpEF. LV dimensions, ejection fraction (EF), mitral annulus peak systolic excursion (MAPSE), myocardial velocities (s’, e’ and a’), LA dimensions and volumes were measured. Total LA emptying fraction (LA EF) was measured by Simpson rule volumes. Based on the NCEP-ATP III criteria, patients were divided into two groups; MetS (n=95) and non-MetS (n=108) and were compared with 34 age and gender matched controls.Results. Age and gender were not different between patients and control neither between MetS and non-Met. LV dimensions, EF and longitudinal function indices were also not different. The MetS patients had higher LV mass index (p=0.038), lower septal and lateral e’ (p=0.003 and p=0.001, respectively) velocities, larger LA minimal volume (p=0.007) and lower LA EF (pConclusions. Despite no difference in LV systolic function, patients with HFpEF and MetS have worse LA emptying fraction, compared with HFpEF and non-MetS patients. In addition, LA reservoir function impairment and MetS independently predict patients limiting symptoms, thus add to a better understanding of HFpEF. |
| Databáze: | OpenAIRE |
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