SHORT TERM VITAMIN E SUPPLEMENTATION HAS NO EFFECT ON PLATELET FUNCTION, PLASMA PHOSPHOLIPASE A2AND LYSO-PAF IN MALE VOLUNTEERS
| Autor: | P L Silbert, Lillian L. L. Leong, Marian Sturm, Roger R. Taylor, Julie A. Strophair |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Platelet Aggregation Physiology medicine.medical_treatment Phospholipases A chemistry.chemical_compound Phospholipase A2 Physiology (medical) Internal medicine Blood plasma medicine Humans Vitamin E Single-Blind Method Platelet Tocopherol Platelet Activating Factor Phospholipids Whole blood Pharmacology biology Platelet-activating factor Middle Aged Diet Phospholipases A2 Endocrinology chemistry Platelet-rich plasma biology.protein lipids (amino acids peptides and proteins) |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 17:645-651 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1990.tb01365.x |
| Popis: | SUMMARY 1. Based largely upon in vitro studies, vitamin E has been reported to inhibit phospholipase A2 activity, to alter phospholipid metabolism and reduce platelet aggregation. 2. The effect of dietary supplementation with D-α-tocopherol (1500 iu/day for 14 days) was studied in nine males, 41–63 years old, comparing active treatment with a preceding placebo period. 3. Despite an increase from 2.6±0.8 (s.d.) × 10-5 mol/L to 6.0±1.8 10-5 mol/L in plasma vitamin E there were no significant changes in the aggregation of diluted whole blood or platelet rich plasma to adenosine diphosphate (ADP) or collagen, in plasma phospholipase A2 activity or plasma lyso-platelet-activating factor (lyso-PAF) (bioassay after in vitro acetylation to PAF). 4. High dose vitamin E dietary supplementation had no effect on these phospholipid and platelet parameters. |
| Databáze: | OpenAIRE |
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