Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination
| Autor: | Sámuel Komoly, Marina D. Jeyasingham, O. E. Pratt, Peter L. Lantos |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Carbonic anhydrase II Myelin Cuprizone Mice Carbonic anhydrase Glial Fibrillary Acidic Protein medicine Animals Myelin Sheath Carbonic Anhydrases biology Chemistry Carbonic anhydrase activity Brain Myelin Basic Protein Oligodendrocyte Oligodendroglia medicine.anatomical_structure Superior cerebellar peduncle Neurology Immunology Nerve Degeneration biology.protein Immunohistochemistry Myelin degeneration Neurology (clinical) Neuroglia Demyelinating Diseases |
| Zdroj: | Journal of the neurological sciences. 79(1-2) |
| ISSN: | 0022-510X |
| Popis: | Both immunohistochemical and biochemical evidence is presented to show for the first time that carbonic anhydrase II (CA II) activity falls in the brain of mice in cuprizone (bis(cyclohexanone)oxalyldihydrazone) induced demyelination well before demyelination develops. This fall began during the first week, whereas the first signs of myelin degeneration induced by cuprizone did not appear until 3 weeks and demyelination in the superior cerebellar peduncle in the mouse took 6–8 weeks to develop. The findings suggest that oligodendrocyte CA II activity is essential either for the survival of oligodendrocytes or for the maintenance of central myelin. |
| Databáze: | OpenAIRE |
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