Regulatory mechanism of ferroptosis, a new mode of cell death
| Autor: | Guoya Li, Xuekun Xing, Chenxi Cao, Yanyan Zhao, Ang Jia, Da Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Programmed cell death Chemistry Autophagy Pyroptosis Pharmaceutical Science GPX4 Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Lipid oxidation Apoptosis 030220 oncology & carcinogenesis Ferroptosis Iron Lipid Active oxygen Inhibitor Inducer Pharmacology (medical) Signal transduction Protein kinase A |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 17, No 11 (2018); 2309-2316 |
| ISSN: | 1596-9827 1596-5996 |
| Popis: | Ferroptosis is a newly discovered process of cell death that differs from apoptosis, autophagy, and pyroptosis. It is closely related to tumor formation, diseases that damage tissue, and neurodegenerative diseases. Activation of the extracellular regulated protein kinase (EPK) pathway and acylCOA synthetase long-chain family member 4 (ACSL4) are indicative of ferroptosis. During ferroptosis, the mitochondrial volume becomes smaller and the double membrane density increases. The process of ferroptosis involves disruption of the material redox reaction, and changes in the levels of cystine, glutathione, NADPH, and increase of GPX4, NOX, and ROS. Iron increases significantly in ferroptosis. Divalent iron ions can greatly promote lipid oxidation, ROS accumulation, and thus promote ferroptosis. The occurrence and progress of ferroptosis are influenced by multiple factors and signaling pathways. Keywords: Ferroptosis, Iron; Lipid, Active oxygen, Inhibitor, Inducer |
| Databáze: | OpenAIRE |
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