Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression
| Autor: | Zheng Li, Brian E. Gilbert, George V. Letsou, John C. Baldwin, Christos N Klonaris, Mehmet Umit Ergenoglu, Hazim J. Safi, J.C. Waldrep, Michael J. Reardon |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty medicine.medical_treatment Pharmacology Dogs Pharmacokinetics medicine Animals Lung transplantation Tissue Distribution Particle Size Lung Chromatography High Pressure Liquid Whole blood Aerosols Drug Carriers business.industry Respiratory disease Immunosuppression respiratory system Ciclosporin medicine.disease Transplantation medicine.anatomical_structure Liposomes Cyclosporine Surgery Cardiology and Cardiovascular Medicine business Immunosuppressive Agents Lung Transplantation medicine.drug |
| Zdroj: | The Annals of Thoracic Surgery. 68:2044-2048 |
| ISSN: | 0003-4975 |
| Popis: | Background . The results of pulmonary transplantation are compromised by acute and chronic rejection. We hypothesized that a liposomal form of aerosolized cyclosporine A (CsA) would be selectively deposited and concentrated in the lungs. The theoretical advantage of this therapy is selective pulmonary immunosuppression with prolonged utilization. Methods . Eighteen dogs were endotracheally intubated; aerosolized liposomal CsA was administered for 15 min. CsA levels were measured in whole blood, lung, trachea, heart, kidney, liver, and spleen at various times after treatment. Results . The lung rapidly absorbs aerosolized liposomal CsA; other organs have much lower concentrations. The retention of pulmonary CsA delivered by liposome aerosol is approximately 120 min in this model. Conclusions . Aerosolized liposomal CsA is selectively deposited and concentrated in the lungs; other organs absorb less CsA. |
| Databáze: | OpenAIRE |
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