Risk of haemolytic uraemic syndrome caused by shiga-toxin-producing Escherichia coli infection in adult women in Japan
| Autor: | Y Maruyama, Nobuhiko Okabe, Y Kurozawa, Y Naya, Y Nakada, K Saitoh, T Nakamura, J Fujii, S Ugajin, Yuki Tada, T Kita, T Mizoue, K Joh, H Kishimoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Epidemiology Gb3 Kidney Disease Outbreaks chemistry.chemical_compound 0302 clinical medicine Japan Risk Factors haemolytic uraemic syndrome Renal Insufficiency 030212 general & internal medicine Young adult Child Escherichia coli Infections Aged 80 and over Shiga-Toxigenic Escherichia coli Trihexosylceramides Age Factors Brain Middle Aged Diarrhea STEC Infectious Diseases medicine.anatomical_structure Child Preschool Female medicine.symptom Adult medicine.medical_specialty Adolescent Globotriaosylceramide Young Adult 03 medical and health sciences Sex Factors Internal medicine medicine Humans HUS Risk factor Aged Retrospective Studies business.industry Infant Newborn Infant Outbreak Retrospective cohort study Odds ratio 030104 developmental biology chemistry Hemolytic-Uremic Syndrome business |
| Zdroj: | Fujii J., Mizoue T., Kita T., et al. Risk of haemolytic uraemic syndrome caused by shiga-toxin-producing Escherichia coli infection in adult women in Japan. EPIDEMIOLOGY AND INFECTION. 2016. 144(5). 952-961. doi:10.1017/S0950268815002289 |
| ISSN: | 0950-2688 |
| DOI: | 10.1017/S0950268815002289 |
| Popis: | SUMMARYShiga-toxin-producingEscherichia coli(STEC) infections usually cause haemolytic uraemic syndrome (HUS) equally in male and female children. This study investigated the localization of globotriaosylceramide (Gb3) in human brain and kidney tissues removed from forensic autopsy cases in Japan. A fatal case was used as a positive control in an outbreak of diarrhoeal disease caused by STEC O157:H7 in a kindergarten in Urawa in 1990. Positive immunodetection of Gb3 was significantly more frequent in female than in male distal and collecting renal tubules. To correlate this finding with a clinical outcome, a retrospective analysis of the predictors of renal failure in the 162 patients of two outbreaks in Japan was performed: one in Tochigi in 2002 and the other in Kagawa Prefecture in 2005. This study concludes renal failure, including HUS, was significantly associated with female sex, and the odds ratio was 4·06 compared to male patients in the two outbreaks. From 2006 to 2009 in Japan, the risk factor of HUS associated with STEC infection was analysed. The number of males and females and the proportion of females who developed HUS were calculated by age and year from 2006 to 2009. In 2006, 2007 and 2009 in adults aged >20 years, adult women were significantly more at risk of developing HUS in Japan. |
| Databáze: | OpenAIRE |
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