Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients
| Autor: | Keith W. Muir, Rose Bosnell, James Kennedy, Michael J. Knight, Davide Carone, Robin A. Damion, Bryony L. McGarry, Philip Clatworthy, Peter Jezzard, Risto A. Kauppinen, Salwa El-Tawil, George Harston, Jennifer Elliot |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
acute stroke
Ischemia Grey matter Brain and Behaviour 030218 nuclear medicine & medical imaging diffusion MRI White matter Lesion 03 medical and health sciences 0302 clinical medicine medicine magnetic resonance imaging Effective diffusion coefficient Radiology Nuclear Medicine and imaging Brain Imaging Radiological and Ultrasound Technology medicine.diagnostic_test business.industry T relaxation time Magnetic resonance imaging medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Brain size Cognitive Science medicine.symptom Nuclear medicine business Diffusion MRI |
| Zdroj: | Damion, R A, Knight, M J, McGarry, B L, Bosnell, R, Jezzard, P, Harston, G W J, Carone, D, Kennedy, J, El-Tawil, S, Elliot, J, Muir, K W, Clatworthy, P & Kauppinen, R A 2019, ' Quantifying T 2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients ', Physics in Medicine and Biology, vol. 64, no. 9, 095016 . https://doi.org/10.1088/1361-6560/ab1442 |
| ISSN: | 0031-9155 |
| Popis: | The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T 2 relaxation time changes in ischaemic brain such that T 2 in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T 2 in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T 2 on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We studied whether T 2 changes in the two main cerebral tissue types, i.e. in grey matter (GM) and white matter (WM), would differ in stroke. Thirty-eight acute stroke patients were accrued within 9 h of symptom onset and scanned at 3 T for 3D T 1-weighted, multi b-value diffusion and multi-echo spin echo MRI for tissue type segmentation, quantitative ADC and absolute T 2 images, respectively. T 2 changes measured by the spherical reference method were 1.94 ± 0.61, 1.50 ± 0.52 and 1.40 ± 0.54 ms h-1 in the whole, GM, and WM lesions, respectively. Thus, T 2 time courses were comparable between GM and WM independent of brain tissue type involved. We demonstrate that T 2 changes in ADC-delineated lesions can be quantified in the clinical setting in a user unbiased manner and that T 2 change correlated with symptom onset time, opening the possibility of using the approach as a tool to assess severity of tissue damage in the clinical setting. |
| Databáze: | OpenAIRE |
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