Genetic Linkage of Exotoxin Alleles andemmGene Markers for Tissue Tropism in Group A Streptococci
| Autor: | Debra E. Bessen, Marc W. Izzo, Susan K. Hollingshead, Bernard Beall, Romeo M. Caringal, Therese R. Fiorentino |
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| Rok vydání: | 1999 |
| Předmět: |
Genetic Markers
Streptococcus Phages Genetic Linkage Streptococcus pyogenes Exotoxins Virulence Microbiology Bacterial Proteins stomatognathic system Genetic linkage otorhinolaryngologic diseases Humans Immunology and Allergy Allele Gene Alleles Tropism Genetics Antigens Bacterial biology Chromosome Mapping Membrane Proteins Chromosomes Bacterial bacterial infections and mycoses biology.organism_classification stomatognathic diseases Infectious Diseases Genes Bacterial Genetic marker Spea Tissue tropism Carrier Proteins Bacterial Outer Membrane Proteins |
| Zdroj: | The Journal of Infectious Diseases. 179:627-636 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/314631 |
| Popis: | In group A streptococci, genetic markers for principal tissue reservoir are located within emm genes, which encode surface proteins that have a role in virulence. A worldwide collection of 160 isolates was evaluated for two traits: chromosomal emm gene markers for tissue tropism (designated patterns A-E), and bacteriophage-associated genes (speA and speC) encoding pyrogenic exotoxins. The speA and speC alleles of organisms harboring the emm marker for a pharyngeal reservoir (pattern A-C) differ from spe alleles that predominate in organisms with the emm marker for impetigo (pattern D). However, organisms that display the emm marker for both tissue sites (pattern E) are not intermediate for the distribution of either speA or speC alleles, but instead resemble pattern A-C isolates for speA and pattern D strains for speC. Statistically significant nonrandom associations between exotoxin alleles and emm patterns were observed but cannot be readily explained by niche separation alone. |
| Databáze: | OpenAIRE |
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