Surface expression and distribution of voltage-gated potassium channels in neurons (Review)

Autor:	Lynn McKeown, Philip Robinson, Lisa Swanton, Owen T. Jones
Rok vydání:	2008
Předmět:	Neurons Inward-rectifier potassium ion channel Chemistry Cell Membrane Nanotechnology Cell Biology Voltage-gated potassium channel Control cell Potassium channel Protein Transport Gene Expression Regulation Potassium Channels Voltage-Gated Animals Surface expression Molecular Biology Neuroscience Ion channel
Zdroj:	Molecular Membrane Biology. 25:332-343
ISSN:	1464-5203 0968-7688
DOI:	10.1080/09687680801992470
Popis:	The last decade has witnessed an exponential increase in interest in one of the great mysteries of nerve cell biology: Specifically, how do neurons know where to place the ion channels that control their excitability? Many of the most important insights have been gleaned from studies on the voltage-gated potassium channels (Kvs) which underlie the shape, duration and frequency of action potentials. In this review, we gather recent evidence on the expression, trafficking and maintenance mechanisms which control the surface density of Kvs in different subcellular compartments of neurons and how these may be regulated to control cell excitability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5eaa85a06941948875e05b6486470e0 https://doi.org/10.1080/09687680801992470 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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