Short Term Performance Evaluation of a Perfluorocopolymer Coated Gas Exchanger for Arteriovenous CO2 Removal
| Autor: | Stuart Nemser, Dongfang Wang, Scott K. Alpard, Joseph B. Zwischenberger, Hussein N. Yamani, Clare Savage, Donald J. Deyo |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Cardiac output Biomedical Engineering Biophysics Plasma leakage Hemodynamics Bioengineering Short term performance Biomaterials Random Allocation Extracorporeal Membrane Oxygenation Coated Materials Biocompatible Jugular vein Co2 removal medicine Animals Cardiac Output Fluorocarbons Sheep Chromatography Pulmonary Gas Exchange Chemistry General Medicine Blood flow Carbon Dioxide Surgery Fluorocarbon Polymers Models Animal Vascular Resistance Large animal |
| Zdroj: | ASAIO Journal. 49:673-677 |
| ISSN: | 1058-2916 |
| Popis: | A new perfluorocopolymer coating for micropore hollow fiber gas exchangers was developed to improve gas exchange, reduce plasma leakage, and reduce blood-surface interactions. The present authors evaluated gas exchanger performance using this new coating in a prospective, randomized, controlled, unblinded, large animal model of CO 2 retention. Adult sheep (30-40 kg), under general anesthesia, underwent cannulation of the carotid artery (12 F) and jugular vein (14 F). The perfluorocopolymer coated (n = 5) and uncoated (n = 5) gas exchangers were attached to an arteriovenous CO 2 removal (AVCO 2 R) circuit. Blood gases, CO 2 removal, and hemodynamics were monitored throughout the 6 hour study. Average CO 2 removal was 107.6 ′ 15.6 ml/min (coated) vs. 93.0 ′ 13.9 ml/min (uncoated; p < 0.01). PaCO 2 and CO 2 removal for both coated and uncoated did not deteriorate significantly over the study. Average AVCO 2 R blood flow was 1,130 ′ 25 ml/min (coated) versus 1,101 ′ 79 ml/min (uncoated; p = not significant). Likewise, cardiac output and AVCO 2 R blood flow did not change over the duration of the study. No significant differences in the pressure gradient or resistance between devices (coated, 6.89 ′ 1.14 mm Hg/L/ min; uncoated, 6.42 ′ 0.23 mm Hg/L/min) was noted. The authors concluded that the new perfluorocopolymer coated gas exchanger improved CO 2 removal without compromising hemodynamics in an acute performance evaluation. |
| Databáze: | OpenAIRE |
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