Juvenile-Onset Recurrent Respiratory Papillomatosis in the United States, Epidemiology and HPV Types-2015-2020

Autor:	Lauri E. Markowitz, Raiza Amiling, Elissa Meites, Laura Stone, Troy D. Querec, Elizabeth R. Unger, Craig S. Derkay, Vidisha Singh
Rok vydání:	2021
Předmět:	Adult medicine.medical_specialty Pediatrics Human Papilloma Virus Vaccine Article 03 medical and health sciences Young Adult 0302 clinical medicine Severity of illness Epidemiology Medicine Humans 030212 general & internal medicine Papillomavirus Vaccines 030223 otorhinolaryngology Child Respiratory Tract Infections business.industry Medical record Papillomavirus Infections General Medicine Odds ratio Confidence interval United States Vaccination Infectious Diseases Logistic Models Pediatrics Perinatology and Child Health Recurrent Respiratory Papillomatosis business
Zdroj:	J Pediatric Infect Dis Soc
ISSN:	2048-7207
Popis:	Background Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare disease characterized by the growth of papillomas in the respiratory tract. In the United States, JORRP is not a nationally notifiable condition and current data are limited. Methods Children with JORRP aged Results Among 215 children with JORRP, 88.8% were delivered vaginally; 64.2% were firstborn. Among 190 mothers, the median delivery age was 22 years. Among 114 (60.0%) age-eligible for HPV vaccination, 16 (14.0%) were vaccinated, 1 (0.9%) before delivery. Among 162 specimens tested, 157 (96.9%) had detectable HPV; all 157 had a vaccine-preventable type. Disease severity was associated with younger diagnosis age and HPV 11; adjusted analyses found only younger diagnosis age significant (adjusted odds ratio: 6.1; 95% confidence interval: 2.9, 12.8). Conclusions Children with JORRP were commonly firstborn and delivered vaginally to young mothers; most of the mothers reported no HPV vaccination before delivery. Vaccine-preventable HPV was identified in all specimens with detectable HPV. Increasing preexposure HPV vaccination could substantially reduce or eliminate JORRP in the United States.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e2c8473fd4b92ca4f669e464d264f5 https://pubmed.ncbi.nlm.nih.gov/34145881 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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