Frontal–striatal abnormalities underlying behaviours in the compulsive–impulsive spectrum
| Autor: | Henk J. Groenewegen, Erik Ch. Wolters, Stella J. de Wit, Henk W. Berendse, Dick J. Veltman, Kim M.W. Verhoef, Ysbrand D. van der Werf, Odile A. van den Heuvel |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Other departments, Anatomy and neurosciences, Psychiatry, Neurology, NCA - Brain Imaging, NCA - Neurodegeneration |
| Rok vydání: | 2010 |
| Předmět: |
Impulse control disorder
Addiction media_common.quotation_subject Parkinson Disease Disease medicine.disease Models Biological Corpus Striatum Frontal Lobe Central nervous system disease Cocaine-Related Disorders Degenerative disease Neurology Punding Neural Pathways Compulsive Behavior medicine Humans Neurology (clinical) Psychology Neuroscience Obsessive-compulsive disorder (OCD) Anxiety disorder media_common |
| Zdroj: | Journal of the Neurological Sciences, 289, 55-59. Elsevier B.V. Journal of the neurological sciences, 289(1-2), 55-59. Elsevier van den Heuvel, O A, van der Werf, Y D, Verhoef, K M W, de Wit, S, Berendse, H W, Wolters, E C, Veltman, D J & Groenewegen, H J 2010, ' Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum ', Journal of the Neurological Sciences, vol. 289, no. 1-2, pp. 55-59 . https://doi.org/10.1016/j.jns.2009.08.043 Journal of the Neurological Sciences, 289(1-2), 55-59. Elsevier |
| ISSN: | 0022-510X |
| Popis: | In this paper, we tentatively bring together the psychiatric, neurological and addiction perspectives on the impulsive-compulsive spectrum of neuropsychiatric disorders, in order to understand the pathophysiology of impulse control disorders (ICDs) in Parkinson's disease. In an attempt to try to pool the various levels of information we will therefore focus on three disorders within the impulse-compulsive spectrum, i.e., obsessive-compulsive disorder (OCD), ICDs in Parkinson's disease, and cocaine seeking behaviour. Whereas there are large differences between these three domains, each with their own nomenclature, hypotheses and study results, they share the focus on an imbalance within and between the frontal-striatal circuits as underlying substrate for the behaviours. For each disorder, we summarize the results from recent studies in order to describe in which way alterations in the frontal-striatal circuits contribute to the phenotype. The phenomenological overlap between ICDs in Parkinson's disease, addiction and OCD needs further investigation, since better understanding of the overlapping and differentiating characteristics will contribute to our understanding of the pathophysiology of the disturbances and treatment alternatives. |
| Databáze: | OpenAIRE |
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