Second Primary Malignancy Risk in Thyroid Cancer Survivors: A Systematic Review and Meta-Analysis
| Autor: | Luciana Parlea, Richard W. Tsang, Amiram Gafni, David P. Goldstein, Shereen Ezzat, Anna M. Sawka, Lorne Rotstein, Lehana Thabane, Sharon E. Straus, Irada Ibrahim-Zada, Shoba Subramanian, James D. Brierley |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Incidence Endocrinology Diabetes and Metabolism Incidence (epidemiology) Neoplasms Second Primary Second primary cancer Malignancy medicine.disease Endocrinology Chemotherapy Adjuvant Risk Factors Internal medicine Meta-analysis medicine Humans Genetic Predisposition to Disease Radiotherapy Adjuvant Thyroid Neoplasms business Thyroid cancer |
| Zdroj: | Thyroid. 17:1277-1288 |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | To determine the risk of second primary malignancies (SPMs) in thyroid cancer survivors.We performed a systematic review and meta-analysis examining the standardized incidence ratios (SIRs) of SPMs in thyroid cancer survivors (compared to individuals without thyroid cancer). Two independent reviewers screened citations and reviewed all full-text papers deemed potentially relevant. Final consensus was reached on inclusion of papers in the review. Data were pooled using fixed effects models.Thirteen full-text papers were included. The incidence of SPMs in thyroid cancer survivors was increased with an SIR of 1.20 (95% confidence interval 1.17, 1.24) (based on pooled data from six studies of 70,844 thyroid cancer survivors). The SIR of the following SPMs was significantly increased: salivary gland, stomach, colon/colorectal, breast, prostate, kidney, brain/central nervous system, soft tissue sarcoma, non-Hodgkin's lymphoma, multiple myeloma, leukemia, bone/joints, and adrenal. A significantly reduced risk of lung and cervical cancers was observed.Thyroid cancer survivors are at increased risk of SPMs, which may be related to disease-specific treatments or genetic predisposition. |
| Databáze: | OpenAIRE |
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