P-wave characteristics and histological atrial abnormality
| Autor: | Pyotr G. Platonov, Petter Holmberg, Lubov Mitrofanova, Yan Huo, Fredrik Holmqvist, Victoria Orshanskaya |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adipose tissue Action Potentials Electrocardiography Left atrial wall Trichrome Heart Conduction System Heart Rate Fibrosis Internal medicine Atrial Fibrillation medicine Humans Myocytes Cardiac Sinus rhythm Heart Atria cardiovascular diseases Aged Aged 80 and over Atrium (architecture) business.industry P wave Histology Interatrial Block Middle Aged medicine.disease cardiovascular system Cardiology Female Crest Abnormality Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Electrocardiology. 47:275-280 |
| ISSN: | 0022-0736 |
| DOI: | 10.1016/j.jelectrocard.2014.01.011 |
| Popis: | Introduction: Fibro-fatty transformation of atrial walls is believed to be the leading cause of deteriorated atrial conduction, however any direct assessment of fibrosis extent in the major atrial conduction routes in relation to P-wave characteristics is lacking. We aimed at assessing P-wave morphology and duration in relation to histology of atrial myocardium. Method: Atrial specimens from 11 patients died from cardiovascular causes (7 men; median age 73 years, range 54-82) were collected. Tissue samples were taken at the level of superior and inferior pulmonary veins, center of posterior left atrial wall, Terminal Crest (CT) and Bachmann's Bundle (BB) and stained with Masson's trichrome for assessment of fibrosis and fatty tissue extent at all locations. Standard 12-lead ECGs in sinus rhythm recorded during hospital stay were retrieved from medical records, scanned for manual assessment of PWD and P-wave morphology. Partial Interatrial Block (pIAB) was defined as prolonged (≥120 ms) and bimodal P-wave in any lead on a standard 12-lead ECG. Results: The median PWD was 160 (range 120-200) ms. Fibrosis extent in CT highly correlated to PWD (r=0.914, p |
| Databáze: | OpenAIRE |
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