Evaluation of Oxidative Status in Patients Treated with Electroconvulsive Therapy

Autor: Hasan Herken, Ali Korkmaz, Bunyamin Kaptanoglu, Hülya Aybek, Mahmut Şenyurt
Rok vydání: 2017
Předmět:
neuroleptic agent
medicine.medical_treatment
antioxidant activity
medicine.disease_cause
electroconvulsive therapy
Behavioral Neuroscience
0302 clinical medicine
Electroconvulsive therapy
Total antioxidant status
oxidative stress
antidepressant agent
Pharmacology (medical)
Depression (differential diagnoses)
bipolar disorder
clinical article
adult
malonaldehyde
aerobic metabolism
Mood stabilizer
biological marker
Psychiatry and Mental health
female
Schizophrenia
mood stabilizer
blood sampling
Original Article
medicine.medical_specialty
medicine.drug_class
anxiolytic agent
psychopharmacotherapy
behavioral disciplines and activities
Article
smoking
03 medical and health sciences
male
Internal medicine
mental disorders
medicine
controlled study
In patient
human
Bipolar disorder
business.industry
medicine.disease
Oxidative stress index
030227 psychiatry
schizophrenia
Total oxidant status
major depression
business
030217 neurology & neurosurgery
Oxidative stress
trolox C
Blood sampling
Zdroj: Clinical Psychopharmacology and Neuroscience
ISSN: 2093-4327
1738-1088
DOI: 10.9758/cpn.2017.15.1.40
Popis: Objective: Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress. Methods: Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs. Results: TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006). Conclusion: As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed. Copyright © 2017, Korean College of Neuropsychopharmacology.
Databáze: OpenAIRE
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