| Autor: |
Sibylle Maletz, Henner Hollert, Petra Waldmann, Elke Rabbow, Birgit Kneib-Kissinger, Rita Heinze, Martina Knauer, Tamara Grummt, Tobias Schulze, Thomas Braunbeck, Alexander Eckhardt, Arnold Bahlmann, Walter Meinl, Hansruedi Glatt, Jochen Kuckelkorn, Walter Schadenboeck, Sebastian Feles, Christine E. Hellweg, Werner Brack, Thomas-Benjamin Seiler, Daniel Stengel, Carsten K. Schmidt, Stefan Gartiser, Martin Krauss, Ralf Junek, Petra Rettberg, Eberhard Küster, Abu Noman, Luis F. Spitta, Christa Baumstark-Khan, Meike Kramer, Regine Redelstein, Eva-Maria Prantl |
| Předmět: |
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| Zdroj: |
Scopus-Elsevier |
| Popis: |
This article introduces ‘Tox-Box’, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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