HLA class II transgenic mice: models of the human CD4+ T-cell immune response
| Autor: | Sarah L. Parry, Salil D. Patel, Sara A. Michie, Grete Sønderstrup, Lars Fugger, Norbert Hain, Frances Hall, Andrew P. Cope, Mauro Congia, Hush O. McDevitt |
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| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
Genetically modified mouse Cellular immunity Transgene Immunology Genetic transfer Mice Transgenic Biology Major histocompatibility complex medicine.disease_cause Autoantigens Models Biological Epitope Autoimmune Diseases Autoimmunity Disease Models Animal Mice Immune system HLA-DR4 Antigen biology.protein medicine Animals Humans Immunology and Allergy |
| Zdroj: | Immunological Reviews. 172:335-343 |
| ISSN: | 1600-065X 0105-2896 |
| DOI: | 10.1111/j.1600-065x.1999.tb01377.x |
| Popis: | This review examines the field of current HLA class II transgenic mouse models and the individual approaches applied in production of these mice. The majority of these mice have been created with the objective of obtaining a disease model with clinical features mimicking human autoimmune disease. The development process of a different type of HLA class II transgenic mice, which are designed to function as a substitute for a normal human immune system in studies of human autoantigens, is described. Several HLA-DR4 transgenic lines with normally expressed HLA-DR4 molecules have been produced. To obtain adequate positive selection of the HLA-DR4-restricted CD4+ T-cell repertoire in these mice it is essential both to introduce a human CD4 transgene, and to delete the murine major histocompatibility complex (MHC) class II molecules. These HLA-DR4 transgenic mice have been used to determine the immunogenic CD4+ T-cell epitopes of several human autoantigenic proteins. |
| Databáze: | OpenAIRE |
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