Advanced Photonic Sensors Based on Interband Cascade Lasers for Real-Time Mouse Breath Analysis
| Autor: | Martin Wepler, Christian Wolf, Josef Vogt, Erhan Tütüncü, Peter Radermacher, Johannes Koeth, S. Becker, Volker Ribitsch, Sandra Kress, Michael Gröger, Markus Nägele, Marc Fischer, Andrea Teuber, Boris Mizaikoff, Stefan Köstler, Ulrich Wachter |
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| Přispěvatelé: | European Union (EU), Horizon 2020 |
| Jazyk: | angličtina |
| Předmět: |
Time delay and integration
DDC 540 / Chemistry & allied sciences Materials science Spectrophotometry Infrared electrospun polymer nanofiber Bioengineering 02 engineering and technology Interband cascade laser 01 natural sciences Gas Chromatography-Mass Spectrometry law.invention Photoacoustic Techniques Mice isotope enrichment law Breath tests Animals Allan variance Instrumentation Fluid Flow and Transfer Processes Carbon Isotopes business.industry Lasers substrate integrated hollow waveguide Process Chemistry and Technology Wellenleiter 010401 analytical chemistry Isotop Carbon Dioxide 021001 nanoscience & nanotechnology Laser breath analysis Carbon Substrate integrated waveguides 0104 chemical sciences Oxygen Isotope separation Hohlleiter Breath gas analysis ddc:540 interband cascade laser Optoelectronics Photonics 0210 nano-technology business Luminescence Oxygen sensor |
| Zdroj: | ACS Sensors |
| ISSN: | 2379-3694 |
| DOI: | 10.1021/acssensors.8b00477 |
| Popis: | A multiparameter gas sensor based on distributed feedback interband cascade lasers emitting at 4.35 ��m and ultrafast electro-spun luminescence oxygen sensors has been developed for the quantification and continuous monitoring of 13CO2/12CO2 isotopic ratio changes and oxygen in exhaled mouse breath samples. Mid-infrared absorption spectra for quantitatively monitoring the enrichment of 13CO2 levels were recorded in a miniaturized dual-channel substrate-integrated hollow waveguide using balanced ratiometric detection, whereas luminescence quenching was used for synchronously detecting exhaled oxygen levels. Allan variance analysis verified a CO2 measurement precision of 1.6��� during a 480 s integration time. Routine online monitoring of exhaled mouse breath was performed in 14 mechanically ventilated and instrumented mice and demonstrated the feasibility of online isotope-selective exhaled breath analysis within microliters of probed gas samples using the reported combined sensor platform. acceptedVersion |
| Databáze: | OpenAIRE |
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