Is oleic acid the thyroxine binding inhibitor in the serum of ill patients?
| Autor: | Arthur R. Bradwell, N. J. Fitch, David B. Ramsden, S. J. Lockett, I. G. Haynes, Michael C. Sheppard, M. Farmer |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Globulin Endocrinology Diabetes and Metabolism Radioimmunoassay Oleic Acids Immunoelectrophoresis Plasma protein binding chemistry.chemical_compound Thyroxine-Binding Proteins Endocrinology Internal medicine medicine Humans Postoperative Period medicine.diagnostic_test biology Chemistry Blood Proteins Blood proteins Oleic acid Thyroxine biology.protein lipids (amino acids peptides and proteins) Arachidonic acid Thyroxine-binding proteins Oleic Acid Protein Binding |
| Zdroj: | Clinical endocrinology. 31(1) |
| ISSN: | 0300-0664 |
| Popis: | The possibility that oleic acid is the thyroxine binding inhibitor in the serum of seriously ill patients was investigated. 3H-Oleic acid was shown to bind directly to human thyroxine-binding globulin (TBG) by the techniques of one and two-dimensional immunoelectrophoresis in combination with autoradiography. However, no correlation was seen between serum thyroxine concentration and oleic acid concentration in two groups of patients, one of which underwent routine cholecystectomy, whilst the other group was admitted to an intensive therapy unit (mortality 75%). No correlation was seen between serum total thyroxine concentration and either stearic, palmitic, linoleic or arachidonic acid concentrations in these groups. Therefore, it was concluded that oleic acid was unlikely to be the circulating inhibitor of thyroxine binding. |
| Databáze: | OpenAIRE |
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