Second autologous stem cell transplantation for relapsed/refractory Hodgkin lymphoma after a previous autograft: a study of the lymphoma working party of the EBMT

Autor:	Edgar Faber, Aida Botelho de Sousa, Ibrahim Yakoub-Agha, Irma Khvedelidze, Xavier Poiré, Ariane Boumendil, Joanna Romejko-Jarosinska, Anna Sureda, Herve Finel, Hervé Ghesquières, Kazimierz Hałaburda, Achilles Anagnostopoulos, Saad Akhtar, Carmen Martínez, Silvia Montoto, Vincenzo Pavone, Gunhan Gurman
Rok vydání:	2020
Předmět:	Oncology Cancer Research medicine.medical_specialty Lymphoma medicine.medical_treatment Hematopoietic stem cell transplantation Transplantation Autologous Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Refractory Recurrence immune system diseases hemic and lymphatic diseases Internal medicine Refractory Hodgkin Lymphoma medicine Humans Autografts business.industry Hematopoietic Stem Cell Transplantation Hematology medicine.disease Hodgkin Disease 030220 oncology & carcinogenesis Relapsed refractory Hodgkin lymphoma Neoplasm Recurrence Local business Stem Cell Transplantation 030215 immunology
Zdroj:	Leukemia & Lymphoma. 61:2915-2922
ISSN:	1029-2403 1042-8194
Popis:	The purpose of this study was to analyze the results of second autologous hematopoietic stem cell transplantation (ASCT2) for patients with relapsed/refractory Hodgkin lymphoma (HL) after a first transplantation (ASCT1). Outcomes for 56 patients receiving an ASCT2 registered in the EBMT database were analyzed. The 4-year cumulative incidences of non-relapse mortality and disease relapse/progression were 5% and 67%, respectively. The 4-year overall survival (OS) and progression-free survival (PFS) were 62% and 28%. In univariate analysis, relapse of HL within 12 months of ASCT1 was associated with a worse OS (35% versus 76%
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d216409882c2cdec1343da1eba7e41 https://doi.org/10.1080/10428194.2020.1789624 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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