miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3

Autor:	Rui Jorge Nobre, Diana D. Lobo, Carina Henriques, Sonia P. Duarte, Sara M. Lopes, Ana C. Silva, Miguel M. Lopes, Fanny Mariet, Lukas K. Schwarz, M.S. Baatje, Valerie Ferreira, Astrid Vallès, Luis Pereira de Almeida, Melvin M. Evers, Lodewijk J.A. Toonen
Rok vydání:	2022
Předmět:	Machado-Joseph Disease Biochemistry Repressor Proteins Disease Models Animal Mice MicroRNAs Trinucleotide Repeats Gene Knockdown Techniques Drug Discovery Genetics Animals Molecular Medicine Ataxin-3 Molecular Biology
Zdroj:	Nucleic Acid Therapeutics. 32:194-205
ISSN:	2159-3345 2159-3337
Popis:	Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by the expansion of a CAG repeat in the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d123850adffcbdcb04be75b9bfabd3 https://doi.org/10.1089/nat.2021.0020 Zobrazit plný text záznamu