Updates on urinary tract infections in kidney transplantation
| Autor: | Marco Fiorentino, Loreto Gesualdo, Giuseppe Castellano, Simona Simone, Antonio Schena, Francesco Pesce |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
medicine.medical_specialty medicine.drug_class Urinary system Antibiotics 030232 urology & nephrology Disease 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Internal medicine medicine Humans Urinary Tract Intensive care medicine Kidney transplantation Kidney business.industry Incidence Microbiota Decision Trees medicine.disease Kidney Transplantation Treatment Outcome medicine.anatomical_structure Bacteremia Urinary Tract Infections medicine.symptom business |
| Zdroj: | Journal of Nephrology. 32:751-761 |
| ISSN: | 1724-6059 1121-8428 |
| Popis: | Urinary tract infection (UTI) represents the most common infection after kidney transplantation; it is associated with an increased risk for acute kidney rejection and impaired graft function in the early post-transplant period. Kidney transplant recipients with UTIs are often clinically asymptomatic due to the immunosuppressive therapy; however, asymptomatic bacteriuria may progress to acute pyelonephritis, bacteremia and urosepsis, particularly in the early post-transplant period, that are independent risk factors for short and long-term graft and patient survival. This article reviews the definitions, incidence, risk factors and the management of UTI in kidney transplant recipients; furthermore, the main controversial and still unanswered questions, regarding the causes of recurrent UTIs, adequate use of antibiotics to avoid antibiotic resistance, dosing and timing for prophylaxis and treatment of symptomatic infections, are also discussed. The emerging definition of urinary microbiota introduces new concepts in understanding the complexity of the disease and might represent the future target for therapeutic interventions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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