ROLE OF NITRIC OXIDE IN NMDA-EVOKED RELEASE OF [3H]-DOPAMINE FROM STRIATAL SLICES
| Autor: | Joseph A. Gally, David A. Wink, Yoichi Osawa, Ingeborg Hanbauer, Gerald M. Edelman |
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| Rok vydání: | 1992 |
| Předmět: |
N-Methylaspartate
Dopamine In Vitro Techniques Biology Nitric Oxide Tritium Nitric oxide chemistry.chemical_compound medicine Animals Neurotransmitter Receptor Cells Cultured General Neuroscience Glutamate receptor Rats Inbred Strains Tetrahydrobiopterin Corpus Striatum Rats nervous system chemistry Tetrodotoxin Biophysics NMDA receptor Female Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 3:409-412 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199205000-00008 |
| Popis: | Evidence that excitatory amino acids act via N-methyl-D-aspartate (NMDA) receptors to evoke the release of catecholamines from axonal terminals and synaptosomes has been used to argue for the presence of pre-synaptic NMDA receptors. NMDA receptor agonists also generate nitric oxide (NO) which rapidly diffuses through neural tissue. We find that exogenously applied NO evokes [3H]-dopamine release from cultured neurons. This release is not blocked by the NMDA antagonist MK-801 nor by tetrodotoxin. Both NG-nitroarginine which inhibits NO synthesis, and hemoglobin which binds extracellular NO, block NMDA-evoked [3H]-dopamine release from striatal slices. A major role of endogenously-synthesized NO may be to evoke neurotransmitter release in local volumes of neural tissue. |
| Databáze: | OpenAIRE |
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