Decreased food anticipatory activity of obese mice relates to hypothalamic c-Fos expression
| Autor: | Manuel Miranda-Anaya, Cesar Luna‐Illades, Teresa Morales |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cingulate cortex Male medicine.medical_specialty Period (gene) Hypothalamus Hippocampus Gene Expression Mice Obese Experimental and Cognitive Psychology Biology Motor Activity c-Fos 03 medical and health sciences Behavioral Neuroscience Eating 0302 clinical medicine Limbic system Internal medicine medicine Limbic System Animals Obesity Obese Mice Neurons medicine.disease Anticipation Psychological Actigraphy 030104 developmental biology medicine.anatomical_structure Endocrinology biology.protein Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery |
| Zdroj: | Physiologybehavior. 179 |
| ISSN: | 1873-507X |
| Popis: | During daily Food Restriction (FR), obese Neotomodon alstoni mice present decreased Food Anticipatory Activity (FAA) compared to lean mice. Here, we investigated whether FOS expression in hypothalamic nuclei involved in food synchronization and anticipation parallels decreased FAA during daily FR of obese N. alstoni. Locomotor activity of lean and obese mice in ad libitum feeding conditions was monitored for at least two weeks. Then, a gradual restriction of food access was followed to establish a 5h period of daily food access. FR was maintained during at least two weeks before sacrifice of mice at the starting point of the feeding period. Obese mice subjected to FR displayed an overall reduction of FOS-positive (FOS+) hypothalamic neurons, while lean mice in a similar protocol exhibited an increase in FOS+ neurons within the arcuate and dorsomedial hypothalamic nuclei. These results are consistent with decreased FAA displayed by obese mice in comparison to lean mice. Furthermore, limbic system areas of lean mice, such as the cingulate cortex and the hippocampus, showed an increase in FOS during FR, while no responses were observed in obese mice. The daily food intake of obese mice was severely reduced during FR, compared to the ad libitum condition, whereas food intake in lean mice was not affected by FR. Current data suggests that decreased hypothalamic and limbic neuronal activation may contribute to the reduction of FAA in obese N. alstoni mice. |
| Databáze: | OpenAIRE |
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