Clinical significance of chemokine receptor CXCR4 and mammalian target of rapamycin (mTOR) expression in patients with diffuse large B-cell lymphoma

Autor: Junmin Li, Jian-Kang Shen, Shu-Qing Zhao, Zi-Zhen Xu
Rok vydání: 2017
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Receptors
CXCR4
CXCR4 Inhibitor
Combination therapy
Gene Expression
Biology
CXCR4
03 medical and health sciences
Chemokine receptor
Antibodies
Monoclonal
Murine-Derived
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Molecular Targeted Therapy
Cyclophosphamide
PI3K/AKT/mTOR pathway
Aged
Retrospective Studies
Aged
80 and over
Everolimus
TOR Serine-Threonine Kinases
Hematology
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Lymphoma
Endocrinology
Oncology
Doxorubicin
Vincristine
030220 oncology & carcinogenesis
Cancer research
Prednisone
Female
Lymphoma
Large B-Cell
Diffuse
Rituximab
Diffuse large B-cell lymphoma
030215 immunology
medicine.drug
Zdroj: Leukemialymphoma. 59(6)
ISSN: 1029-2403
Popis: To assess the relevance of C-X-C chemokine receptor type 4 (CXCR4) and mammalian target of rapamycin (mTOR) to large-B-cell lymphoma (DLBCL), levels of protein expression were measured in 56 DLBCL patients who had received rituximab-based therapy. Of these, 34 were positive for CXCR4 expression (60.7%) and 31 for mTOR (55.4%). CXCR4 expression was positively correlated with mTOR expression (r = 0.602; p = .000). CXCR4 expression was significantly associated with high lactate dehydrogenase (LDH) level (p = .009), high IPI score (p = .030) and non-GCB subtype (p = .006). Furthermore, the expression levels of CXCR4 and mTOR were negatively correlated with the chance of remission (p .05). Kaplan-Meier analysis indicated significantly shorter progression-free survival (PFS) and overall survival (OS) in patients positive for CXCR4 and mTOR expression. The combination therapy with CXCR4 inhibitor WZ811 and mTOR inhibitor everolimus showed syncergistic effect in DLBCL cell lines. These results suggest that the expression of CXCR4 and mTOR may be suitable as biomarkers of the prognosis of DLBCL and for development of new therapeutic strategies.
Databáze: OpenAIRE
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