Inhibitory effect of TS-962 on the formation of early atherosclerotic lesions in high fat-fed hyperlipidemic hamsters
| Autor: | K. Akiyoshi, H. Tomoike, Yumiko Asami, Shohei Higuchi, Izumi Yamagishi, Katsuharu Tsuchida |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Aortic arch medicine.medical_specialty food.ingredient Arteriosclerosis medicine.medical_treatment Hamster Aorta Thoracic Hyperlipidemias Biology chemistry.chemical_compound food Cricetinae Internal medicine medicine.artery Acetamides medicine Animals Oil Red O Enzyme Inhibitors Chemotherapy Cholesterol Vascular disease Body Weight Coconut oil Lipid Metabolism medicine.disease Dietary Fats Staining Disease Models Animal Endocrinology Liver chemistry lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Sterol O-Acyltransferase |
| Zdroj: | Atherosclerosis. 146:237-242 |
| ISSN: | 0021-9150 |
| Popis: | The hypocholesterolemic and anti-atherosclerotic effect of TS-962, a specific ACAT inhibitor, was investigated in a hamster model fed a high fat diet containing 10% coconut oil and 0.05% cholesterol. Lipid accumulated atherosclerotic lesions were detected by using oil red O staining in the lesion-prone aortic arch. A high dose, estimated to be 15 mg/kg, of TS-962 decreased serum cholesterol to normal levels with reduction of liver cholesterol contents below normal levels, and as a consequence, entirely inhibited the lipid accumulation in the aortic arch. Furthermore, a low dose, estimated to be 1.5 mg/kg, of TS-962 remarkably inhibited aortic lipid accumulation by 73% compared with the control group, without changing either serum cholesterol level or liver cholesterol content. These findings suggest that TS-962 is effective in the primary prevention of atherosclerosis by directly suppressing the formation of foam cells in arteries. |
| Databáze: | OpenAIRE |
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